Having played both Bangai-O and Spirits, I was expecting many missiles. The sheer size and number of projectiles when I first launched a MAX attack stays with me, as well as the slowdown, half of which I'm sure was fake.
Bayonetta (Xbox 360)
I am hopeless at the game itself - but I will never forget the car's radio playing Outrun music in the cutscene after the prologue.
Beyond Good & Evil (Xbox)
The final upgrade to your hovercraft ... and suddenly you have a spaceship. Having become familiar with the world over a number of hours, being torn away to pursue the final fight was unsettling.
Bishi Bashi Special (PS)
ATTENTION! Matt didn't read the instructions, and failed time and time again.
Brothers: a Tale of Two Sons (PS3)
Calling upon the bravery and spirit of the elder brother to cross the water. An astounding statement made with no words.
Broken Sword (PS)
Unbelievable slowdown when reaching the desert town. I gave up and played the PC verion a couple of years later.
Having made it to the end of the game, the last corridor and boss were just too difficult. I never completed it and resent the whole thing to this day.